Background: Acute heart failure timely and effective diagnosis and treatment\ndirectly affects the prognosis of patients, so early diagnosis of acute heart failure\ntreatment is very important. The current diagnosis of acute heart failure\nhas yet to be further improved. To investigate the relationship between plasma\nlevels of Galectin-3 and NT-proBNP in cardiac structure and function in patients\nwith acute heart failure (AHF) Early detection of failure. Methods: The\nclinical data of 86 patients with acute heart failure in our hospital were analyzed\nand followed up. Twenty-six healthy subjects with normal cardiac function\nwere used as control group. The plasma Galectin-3 and NT-proBNP levels\nwere compared between the two groups to observe the value of plasma\nGalectin-3 combined with NT-proBNP in the diagnosis of acute heart failure.\nResults: There was no significant difference in the level of Galectin-3 and\nNT-proBNP between heart function group II and control group, and the levels\nof cardiac function III and IVG plasma Galectin-3 and NT-proBNP were\nsignificantly higher in patients with heart failure Compared with the healthy\ncontrol group, the patients� LVEF decreased and their cardiac function increased.\nThe levels of plasma Galectin-3 and NT-proBNP increased significantly\n(P < 0.01). Multivariate Logistic regression analysis demonstrated that\nplasma levels of Galectin-3 and NT-proBNP were independent of cardiac\nfunction. The area under the ROC curve for the combined detection of plasma\nGalectin-3 and NT-proBNP was greater than the area under the two alone\ntests. Conclusion: The combined detection of Galectin-3 and NT-proBNP has\nhigh sensitivity and specificity in the diagnosis of acute heart failure and can\nbe used as a new detection mode.
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